IF you are using GTK 1.4 and are running vista or 7 then switch to GTK 1.5 (only solution that worked for me). For some reason vista and 7 block the save of maps by GTK 1.4
This is a known issue for 1.4, and possibly 1.5
There are two 'solutions' to this problem.
1) Save over another .map file (autosave.map for example)
This is because Radiant can't create a new map file, but it can overwrite
2) Under Edit -> Preferences -> Interface -> Layout, untick 'Use win32 file load dialog'
This will use Radiants native save dialog, which will work (Thanks to mrwonko for finding this fix!)
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